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The neurobehavioral parameters rein cynomolgus monkeys were monitored to assess the CNS-related functional change induced by vacuolation hinein CP, but no differences were observed between animals treated with control or Jintrolong®. hinein clinical trials, Leiter III (360 patients) and L IV (3,000 patients) studies with 26 weeks of treatment demonstrated no statistically significant difference rein the incidence of ARs between the Jintrolong® group and the daily rhGH injection control group. A follow-up study of the L IV with treatment time as long as 3 years in 644 patients was also investigated, and no obvious differences rein the incidence of ARs and CNS-related ARs between the treatment groups were found.

As shown hinein Figures 8A, B, the severity of vacuolation hinein the CP epithelium increases with dose by both average vacuole size and average vacuole ratio (cells with vacuole/total CP epithelial cells). As shown in Figure 8C, no vacuolation was considered to be induced by Jintrolong® in the low dose of 0.3 Magnesium/kg/week Jintrolong® group, as vacuolation was within the background vacuolation Warenangebot in the excipient control group.

Trubel, ich wollte demnächst Fleck jintropin Zu erkennen geben, dass man etwas zu tun gedenkt hab da an so 4 ui gedacht, es sind 12ui/vial das heisst mit 1ml apowasser bekomme ich 12 ui raus oder ?

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Animals hinein the excipient group developed gering vacuoles in the CP epithelium to a similar extent as animals in the low dose 0.3 Magnesium/kg/week Jintrolong® group, with a similar number and size of quantified vacuoles. Thus, CP vacuolation observed hinein animals of the excipient control group is considered as spontaneous vacuolation. The lack of detectable PEG IHC staining hinein the CP of the 0.3 mg/kg/week Jintrolong® group despite observed vacuolation also suggests that no PEG accumulation rein CP cells is found to cause vacuolation.

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The CP cells of each group under TEM were cubic, with abundant microvilli on the surface, and the tight junctions between the cells and the basement membrane on the bottom were intact.